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Clinical Reviews

Remove the ovaries at hysterectomy? Here’s the lowdown on risks and benefits

Oophorectomy causes more harm than good in many women undergoing hysterectomy for benign disease

February 2010 · Vol. 22, No. 02


CASE: Hysterectomy candidate asks about her ovaries

A 51-year-old premenopausal woman complains of severe menorrhagia that often causes her to miss work. Although she is taking an iron supplement, her hemoglobin level often drops below 10 g/dL. She has already been identified as having fibroids, with a uterine size of 14 weeks. You order ultra-sonography, which reveals an enlarged uterus with multiple fibroids and normal endometrial thickness, but no intracavitary lesions.

After you describe the treatment options, including uterine artery embolization, the patient requests a hysterectomy as a reasonably low-risk means of cure. During informed consent, she asks whether she should have her ovaries removed during the surgery. Further discussion reveals that her father died of a myocardial infarction when he was 64 years old, but there is no family or personal history of ovarian or breast cancer.

How do you advise this patient, based on her history and recent findings from medical research?

Many gynecologists have been trained to recommend bilateral oophorectomy for women older than 45 or 50 years who request a hysterectomy for benign disease. In these women, oophorectomy is recommended to prevent ovarian cancer and avert the potential for other ovarian pathology that might require later surgery.

In the United States, 78% of women 45 to 64 years old and 55% of women overall undergo bilateral oophorectomy at the time of hysterectomy. 1 These percentages mean that almost 300,000 women undergo bilateral oophorectomy each year. 1

Hysterectomy alone can sometimes lead to early ovarian failure, but this phenomenon is infrequent. A prospective study of premenopausal women found that, after 5 years of follow-up, 20% of women who underwent simple hysterectomy reached menopause, compared with 7% of matched women who did not undergo hysterectomy. 2

In this article, I explore the risks and benefits associated with bilateral oophorectomy and present an algorithm to aid in deciding whether the patient should keep her ovaries—and when oophorectomy might be a better option ( FIGURE ).

Among the hazards associated with bilateral oophorectomy are:

  • an increased risk of death from coronary artery disease (CAD), lung cancer, all cancers (except ovarian), and all causes 3,4
  • an increased risk of osteoporosis and hip fracture 5
  • when performed before the onset of menopause, an increased risk of parkinsonism, cognitive impairment, dementia, anxiety, and depression. 6-8

Benefits include a reduced risk of ovarian cancer, particularly among women who have a BRCA gene mutation or strong family history of ovarian or breast cancer.

Although ovarian cancer causes 15,000 deaths each year in the United States, that figure pales when compared with heart disease, which accounts for 350,000 deaths. In addition, hip fracture may cause approximately 66,000 deaths each year, and dementia attributable to bilateral oophorectomy may affect 100,000 to 200,000 women. 9 Reoperation for adnexal pathology or pain after hysterectomy is rare, occurring in only 2.8% of women. Therefore, the benefits of oophorectomy are often outweighed by the risks of CAD, hip fracture, and neurologic conditions.

Estrogen and other drugs mitigate the risks associated with oophorectomy—but many women avoid or discontinue these medications

The assumption that medical treatment will ameliorate the risks associated with oophorectomy is unrealistic. Estrogen may mitigate some risks, but many women avoid hormone therapy. This avoidance can be especially problematic in young women.

In the Nurses’ Health Study, a separate analysis focused on women who had never used postmenopausal hormone therapy. 4 In this analysis, all women who underwent bilateral oophorectomy had a greater risk of stroke (HR, 1.85; 95% CI, 1.09, 3.16) and lung cancer (HR, 2.09; 95% CI, 1.01, 4.33) than did women who retained their ovaries. Among women who underwent oophorectomy before age 50 and who did not take estrogen, the risk of coronary artery disease (CAD) was higher (HR, 1.98; 95% CI, 1.18, 3.32), as was the risk of death from all causes (HR, 1.40; 95% CI, 1.01, 1.96), compared with women who retained their ovaries.

Despite estrogen’s proven benefit among oophorectomized women, usage rates continue to decline. In the 6 months after publication of Women’s Health Initiative findings on estrogen–progestin therapy, the continuation rate of estrogen therapy decreased from 12.6% to 9.1%, and new starts also declined significantly. 47

Among women who had a diagnosis of osteoporosis and who began treatment with estrogen, estrogen plus progestin, a bisphosphonate, or raloxifene, medication continuation rates were less than 25% at 12 months. 48 Moreover, only 18% of women started on a statin to reduce the risk of cardiovascular disease were still taking the drug after 1 year. 49

FIGURE Conservation vs oophorectomy: A guide to decision-making

* Estrogen replacement is recommended for women younger than 45 years who opt for oophorectomy

Ovarian cancer is a real, but relatively low, risk

In 2008, an estimated 21,650 new cases of ovarian cancer were diagnosed (age at diagnosis: mean, 63 years), and 15,520 women died from the disease. 10 Because we lack a reliable screening test to detect early-stage ovarian cancer in the general population, most women are given a diagnosis when disease is advanced and the 5-year survival rate is 15% to 25%.

There is agreement that women who are known to have a BRCA mutation, which increases the risk of ovarian and breast cancer, should strongly consider oophorectomy once childbearing is complete. 11 In the general population, however, the outlook is different.

In the United States, the lifetime risk of ovarian cancer is 1.4% overall. Among white women who have had three or more term pregnancies and who have used an oral contraceptive for at least 4 years, the lifetime risk of ovarian cancer drops to 0.3%. 12

Need for reoperation is very low

The percentage of women who require reoperation after ovarian conservation—2.8%—may surprise you. 13 That figure is lower than once thought because many studies were performed before asymptomatic, benign ovarian cysts were determined to be a fairly common phenomenon in postmenopausal women (prevalence, 6.6%). These cysts do not undergo transformation to cancer and, therefore, do not need to be removed. 14

In addition, studies indicate that only 0.1% to 0.75% of women who retain their ovaries at the time of hysterectomy develop ovarian cancer. 15,16 Therefore, the rationale of performing oophorectomy to avoid future surgery appears to be unfounded.

CAD risk rises sharply after oophorectomy

A recent systematic review found mixed evidence concerning the risk of CAD following bilateral salpingo-oophorectomy. 17 In observational studies, however, earlier age of surgical or natural menopause has been associated with a higher risk of cardiovascular mortality. 18-20 Early reports from the Nurses’ Health Study found that the risk of myocardial infarction doubled among women who underwent oophorectomy and never used estrogen, compared with age-matched premenopausal women (relative risk [RR], 2.2; 95% confidence interval [CI], 1.2, 4.2). 3 Even after age 50, the risk of a first myocardial infarction is increased among oophorectomized women, compared with women who retain their ovaries (RR, 1.4; 95% CI, 1.0–2.0). 21

A study by researchers from the Mayo Clinic, who examined all causes listed on the death certificate, found a significant association between bilateral oophorectomy before the age of 45 years and cardiovascular mortality (hazard ratio [HR], 1.44; 95% CI, 1.01–2.05). 22 This risk was significantly increased among women who were not treated with estrogen through at least age 45, compared with estrogen-treated women.

Oophorectomy may impair bone health

After menopause, ovaries continue to produce significant amounts of the androgens testosterone and androstenedione, which are converted to estrone peripherally by skin, muscle, and fat cells. 23,24 The levels of these hormones remain consistent and have been documented to age 80. 25

Both estrogens and androgens inhibit bone resorption, and androgens also stimulate bone formation. 26 Low levels of androgens and estrogens are linked to lower bone density and a higher risk of hip and vertebral fracture in postmenopausal women. 27-29

Postmenopausal women who have been oophorectomized may have an even greater risk of osteoporosis. Over 16 years of follow-up, 340 women who had undergone oophorectomy at a median age of 62 years had 54% more osteoporotic fractures than women who had intact ovaries. 5 Two other studies found no association between oophorectomy and bone loss or fracture risk, however. 30,31

Hip fracture is a well-documented cause of increased morbidity and mortality in older women. One study found that, before hip fracture, 28% of patients were housebound; 1 year after hip fracture, the percentage was 46%. 32 Women older than 60 who underwent oophorectomy had a doubled risk of mortality after low-trauma hip fracture, compared with women who had intact ovaries (odds ratio [OR], 2.18; 95% CI, 2.03–2.32). 5

Loss of ovaries may affect mental health and sexuality

In a premenopausal woman, oophorectomy causes a sudden loss of estrogen and often triggers hot flashes, mood changes, sleep disturbances, headaches, and a decline in feelings of well-being. 33,34 Over time, vaginal dryness, painful intercourse, loss of libido, bladder dysfunction, and depression may occur. 35,36

Evidence suggests that, in women, sexual desire, sexual sensation, and orgasmic response are influenced by androgens. After elective oophorectomy, declines in sexual desire have been reported. 37-39

Mental health and sexuality may rebound over time, however. One study found less improvement in mental health measures and body image 6 months after hysterectomy among women who were oophorectomized, compared with those who retained their ovaries. After 2 years, improvement levels were similar between groups. 40

Cognitive function may suffer

Analysis of data from the Mayo Clinic Cohort Study of Oophorectomy and Aging found that bilateral oophorectomy before the onset of menopause increased the risk of parkinsonism, cognitive impairment or dementia, and anxiety or depression, particularly if estrogen was not replaced. 6-8 These risks increased with younger age at oophorectomy.

The Women’s Health Initiative found an increased risk of dementia or mild cognitive impairment in women who were treated by estrogen alone or estrogen plus progestin after age 65. 41-44

These disparate conclusions suggest that estrogen may have a protective effect on the brain if it is given right after natural menopause or premenopausal oophorectomy, but deleterious effects if it is started years later. 45

Other studies of endogenous estrogen and cognitive function are few and yield inconsistent results.

Ovarian conservation boosts long-term survival

When there is no family history of ovarian cancer, ovarian conservation appears to maximize survival among healthy women 40 to 65 years old who undergo hysterectomy for benign disease. 46 Among healthy women hysterectomized before the age of 55, calculations suggest that 8.6% more would be alive at age 80 if their ovaries were conserved than if they were removed. 46

A study from the Mayo Clinic found that all-cause mortality was significantly higher among women who underwent prophylactic bilateral oophorectomy before the age of 45 than it was among women in the control group (HR, 1.67; 95% CI, 1.16–2.40); it was particularly high in women who did not receive estrogen treatment before age 45 (HR, 1.93; 95% CI, 1.25–2.96). 22

In a recent study, investigators used the Nurses’ Health Study database to explore the long-term health outcomes of 29,380 women who underwent hysterectomy. 4 Of these women, 13,035 (44.4%) had their ovaries conserved, and 16,345 (55.6%) underwent bilateral oophorectomy. Follow-up was 24 years. Oophorectomy was associated with an increased risk of nonfatal CAD among all women (HR, 1.17; 95% CI, 1.02, 1.35), especially those who underwent the procedure before age 45 (HR, 1.26; 95% CI, 1.04, 1.54). Oophorectomy was associated with a markedly reduced risk of ovarian cancer but an increased risk of lung cancer (HR, 1.26; 95% CI, 1.02–1.56).

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