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Examining the Evidence

Does treatment of cervical intraepithelial neoplasia always increase the risk of preterm birth in subsequent gestations?

October 2012 · Vol. 24, No. 10
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Several studies have suggested that the risk of preterm birth increases after treatment for CIN. For example, a meta-analysis of 27 studies found a relative risk (RR) of preterm delivery of 1.70 after treatment for CIN (95% confidence interval [CI], 1.24–2.35).1 Later studies from Nordic countries estimated the RR at 1.8 to 2.8.2,3

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