|November 2009 · Vol. 21, No. 11
Can progesterone prevent prematurity—dependably?
Here’s what we know, after 30 years of study, about the usefulness of progesterone in 4 settings: recurrent preterm birth, multiple gestation, a short cervix, and preterm labor
Infants of women treated with progesterone had significantly lower rates of necrotizing enterocolitis and intravenous hemorrhage and less need for supplemental oxygen
Preterm birth likely arises from different causes in women with a previous preterm birth and women carrying a multiple gestation
A Cochrane review found no harm related to use of progesterone
Dr. Spong is Chief of the Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.
The author reports no financial relationships relevant to this article.