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April 2006 · Vol. 18, No. 4

SURGICAL TECHNIQUE

Preventing VTE: Evidence-based perioperative tactics

The perfect strategy has yet to be devised, but good data point to drug and mechanical methods that come close


Fast Track

2 prophylactic strategies

  • Low-dose heparin, 5,000 U, starting 2 hours before surgery and every 8–12 hours afterward until hospital discharge

  • Low-molecular-weight heparin, 3,400 U per day until discharge

Postop VTE declines 3-fold with external pneumatic compression during surgery and for 5 days postop

80% of symptomatic pulmonary emboli show no signs or symptoms of thrombosis in the lower extremities

Classic pulmonary embolism

  • Pleuritic chest pain

  • Hemoptysis

  • Shortness of breath

  • Tachycardia

  • Tachypnea

Interventions for pulmonary embolism

  • Immediate anticoagulant therapy

  • Respiratory support

  • Embolectomy

  • Pulmonary artery catheterization

  • Vena cava interruption

Daniel  L.  Clarke-Pearson,  MD

Robert A. Ross Professor and Chair, Department of Obstetrics and Gynecology, University of North Carolina,  Chapel Hill, NC

IN THIS ARTICLE

Pulmonary embolism is a master of disguises. It can appear with classic symptoms such as pleuritic chest pain, hemoptysis, and tachycardia—or it can arrive more insidiously, apparent only as a slight elevation in the respiratory rate.

This matters because 40% of all deaths following gynecologic surgery are directly attributable to pulmonary emboli,1 and pulmonary emboli are the most frequent cause of postoperative death in women with uterine or cervical carcinoma.2

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