Estradiol gel: A new option in hormone replacement therapy

An expert profiles percutaneous gel: easy to use, well tolerated, and available in low doses.

Dr. Archer is professor, obstetrics and gynecology, and director, CONRAD Clinical Research Center, Eastern Virginia Medical School, Norfolk, Va.

Although the Women’s Health Initiative¹ discouraged many menopausal women from using oral estrogen, it failed to address the risks of treatment with other dosages or forms of estrogen and progestin.

Nor has any other trial of similar size and complexity taken up the issue. However, numerous smaller studies have been published.