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February 2003 · Vol. 15, No. 2

REIMBURSEMENT ADVISER

Metformin for infertility

Q

If a patient is on metformin for insulin resistance, what is the diagnostic code for insulin resistance if the patient is not pregnant? She will be undergoing in vitro fertilization.

A

Metformin is generally used as an oral agent to help control type 2 diabetes, but your question suggests another use for the drug. Recent evidence indicates that metformin may facilitate ovulation in some women with polycystic ovary syndrome (PCOS) when taken in combination with clomiphene. Since the PCOS usually causes the insulin resistance that may, in turn, cause the infertility, I would suggest PCOS (ICD-9-CM 256.4) as the most accurate diagnosis. Still, infertility remains the primary diagnosis, which means you’ll need to list code 628.0 (female infertility associated with anovulation) first on the claim.

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